Examinando por Autor "Langer, Daniel"

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    Ítem
    Maximal respiratory pressure reference equations in healthy adults and cut-off points for defining respiratory muscle weakness
    (Sociedad Espanola de Neumologia y Cirugia Toracica (SEPAR), 2023-12) Lista Paz, Ana; Langer, Daniel; Barral Fernández, Margarita; Quintela del Río, Alejandro; Gimeno Santos, Elena; Arbillaga Etxarri, Ane; Torres Castro, Rodrigo; Vilaró, Jordi; Varas de la Fuente, Ana B.; Serrano Veguillas, Cristina; Bravo Cortés, Pilar; Martín Cortijo, Concepción; García Delgado, Esther; Herrero Cortina, Beatriz; Valera, José Luis; Fregonezi, Guilherme A.F.; González Montañez, Carolina; Martín Valero, Rocío; Francín Gallego, Marina; Sanesteban Hermida, Yolanda; Giménez Moolhuyzen, Esther; Álvarez Rivas, Jorge; Ríos Cortés, Antonio Tomás; Souto-Camba, Sonia; González Doniz, Luz
    Introduction: Maximal inspiratory and expiratory pressures (PImax/PEmax) reference equations obtained in healthy people are needed to correctly interpret respiratory muscle strength. Currently, no clear cut-off points defining respiratory muscle weakness are available. We aimed to establish sex-specific reference equations for PImax/PEmax in a large sample of healthy adults and to objectively determine cut-off points for respiratory muscle weakness. Methods: A multicentre cross-sectional study was conducted across 14 Spanish centres. Healthy non-smoking volunteers aged 18–80 years stratified by sex and age were recruited. PImax/PEmax were assessed using uniform methodology according to international standards. Multiple linear regressions were used to obtain reference equations. Cut-off points for respiratory muscle weakness were established by using T-scores. Results: The final sample consisted of 610 subjects (314 females; 48 [standard deviation, SD: 17] years). Reference equations for PImax/PEmax included body mass index and a squared term of the age as independent variables for both sexes (p < 0.01). Cut-off points for respiratory muscle weakness based on T-scores ≥2.5 SD below the peak mean value achieved at a young age were: 62 and 83 cmH2O for PImax and 81 and 109 cmH2O for PEmax in females and males, respectively. Conclusion: These reference values, based on the largest dataset collected in a European population to date using uniform methodology, help identify cut-off points for respiratory muscle weakness in females and males. These data will help to better identify the presence of respiratory muscle weakness and to determine indications for interventions to improve respiratory muscle function.
  • Miniatura
    Ítem
    Reference equations for maximal respiratory pressures in healthy children and adolescents
    (Sociedad Espanola de Neumologia y Cirugia Toracica (SEPAR), 2025-09-22) Barral Fernández, Margarita; Jácome Pumar, María Amalia; Souto-Camba, Sonia; González Doniz, Luz; Ramón Belmonte, María Antonia; Amor Barbosa, Marta; Arbillaga Etxarri, Ane; Mazzucco, Guillermo; Bravo Cortés, Pilar; Corral Núñez-Flores, Tamara del; Martín Valero, Rocío; Llorca Cerdà, Carlos; Murcia Lillo, Fabiola; Sanchez Santos, José Antonio; Francín Gallego, Marina; Martín Cortijo, Concepción; García Delgado, Esther; Serrano Veguillas, Cristina; Varas de la Fuente, Ana B.; San José Herranz, Paula; González Montañez, Carolina; Gimeno Santos, Elena; Torres Castro, Rodrigo; Fregonezi, Guilherme A.F.; Pardàs Peraferrer, Mireia; Vilaró, Jordi; Fernández Cadenas, Ángeles; Ríos Cortés, Antonio Tomás; Moreno Valera, María José; Langer, Daniel; Lista Paz, Ana
    Objectives: Maximal respiratory pressures are key indicators of respiratory muscle strength; however, reference equations and cut-offs to define respiratory muscle weakness are scarce in the European paediatric population. The aim was to create sex-specific reference equations for maximal inspiratory and expiratory pressures (PImax/PEmax) in a large sample of healthy children and to objectively establish cut-offs to define respiratory muscle weakness. Methods: A multicentre cross-sectional study was conducted across 14 Spanish centres. Healthy children aged 6–18 years, stratified by sex and age, were recruited. Maximal respiratory pressures were measured following standardized methodology in accordance with international guidelines. Reference equations were developed through multiple linear regression analyses. Age- and sex specific cut-offs for respiratory muscle weakness were determined using Z-scores ≥ 1.645 standard deviation (SD) below group means. Results: The final sample included 513 subjects (257 boys; 11.5 [SD3.5] years). Reference equations are: (1) PImax: boys = −41.41 + 10.21 * age + 6.26 * body mass index (BMI) − 0.37 * age * BMI; girls = 125.96–0.34 * age − 0.41 * age2 − 5.75 * BMI + 0.63 * age * BMI; (2) PEmax: boys = 20.93 + 5.23 * age + 2.93 * BMI; girls = −12.67 + 11.98 * age − 0.39 * age2 + 2.57 * BMI. Cut-offs for respiratory muscle weakness are higher in boys and increase with age (p < .001). Depending on age, PImax cut-offs range from 46 to 85 cmH2O in boys and from 45 to 68 cmH2O in girls, while PEmax cut-offs span 54–98 cmH2O in boys and 57–85 cmH2O in girls. Conclusions: This study provides new reference equations for PImax and PEmax derived from the largest dataset of normative values in European children and adolescents. It also establishes age-specific cut-offs to define respiratory muscle weakness. These findings will facilitate the identification of respiratory muscle weakness and the selection of candidates for targeted training programmes.