Examinando por Autor "Guillamon, Antonio"

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    CBLL1 is hypomethylated and correlates with cortical thickness in transgender men before gender affirming hormone treatment
    (Nature Research, 2023-12-07) Fernández, Rosa; Zubiaurre Elorza, Leire ; Santisteban, Andrea; Ojeda del Pozo, Natalia ; Collet, Sarah; Kiyar, Meltem; T’Sjoen, Guy; Mueller, Sven C.; Guillamon, Antonio; Pásaro, Eduardo
    Gender identity refers to the consciousness of being a man, a woman or other condition. Although it is generally congruent with the sex assigned at birth, for some people it is not. If the incongruity is distressing, it is defined as gender dysphoria (GD). Here, we measured whole-genome DNA methylation by the Illumina © Infinium Human Methylation 850k array and reported its correlation with cortical thickness (CTh) in 22 transgender men (TM) experiencing GD versus 25 cisgender men (CM) and 28 cisgender women (CW). With respect to the methylation analysis, TM vs. CW showed significant differences in 35 CpGs, while 2155 CpGs were found when TM vs. CM were compared. With respect to correlation analysis, TM showed differences in methylation of CBLL1 and DLG1 genes that correlated with global and left hemisphere CTh. Both genes were hypomethylated in TM compared to the cisgender groups. Early onset TM showed a positive correlation between CBLL1 and several cortical regions in the frontal (left caudal middle frontal), temporal (right inferior temporal, left fusiform) and parietal cortices (left supramarginal and right paracentral). This is the first study relating CBLL1 methylation with CTh in transgender persons and supports a neurodevelopmental hypothesis of gender identity.
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    Data for functional MRI connectivity in transgender people with gender incongruence and cisgender individuals
    (Elsevier Inc., 2020-05-15) Uribe, Carme; Junqué i Plaja, Carme; Gómez Gil, Esther; Abos Ortega, Alexandra; Mueller, Sven C.; Guillamon, Antonio
    We provide T2*-weighted and T1-weighted images acquired on a 3T MRI scanner obtained from 17 transwomen and 29 transmen with gender incongruence; and 22 ciswomen and 19 cismen that identified themselves to the sex assigned at birth. Data from three different techniques that describe global and regional connectivity differences within functional resting-state networks in transwomen and transmen with early-in-life onset gender incongruence are provided: (1) we obtained spatial maps from data-driven independent component analysis using the melodic tool from FSL software; (2) we provide the functional networks interactions of two functional atlases’ seeds from a seed-to-seed approach; (3) and global graph-theoretical metrics such as the smallworld organization, and the segregation and integration properties of the networks. Interpretations of the present dataset can be found in the original article, doi:10.1016/j.neuroimage.2020.116613 [1]. The original and processed nifti images are available in Mendeley datasets. In addition, correlation matrices for the seed-to-seed and graph-theory analyses as well as the graph-theoretical measures were made available in Matlab files. Finally, we present supplementary information for the original article.
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    The effects of testosterone on the brain of transgender men
    (Mary Ann Liebert Inc., 2021-12-23) Zubiaurre Elorza, Leire; Cerdán, Sebastián; Uribe, Carme; Pérez-Laso, Carmen ; Marcos Bermejo, Alberto; Rodríguez del Cerro, María Cruz; Fernández García, Rosa; Pásaro, Eduardo; Guillamon, Antonio
    Transgender men (TM) experience an incongruence between the female sex assigned when they were born and their self-perceived male identity. Some TM seek for a gender affirming hormone treatment (GAHT) to induce a somatic transition from female to male through continuous administration of testosterone. GAHT seems to be relatively safe. However, testosterone produces structural changes in the brain as detected by quantitative magnetic resonance imaging. Mainly, it induces an increase in cortical volume and thickness and subcortical structural volume probably due to the anabolic effects. Animal models, specifically developed to test the anabolic hypothesis, suggest that testosterone and estradiol, its aromatized metabolite, participate in the control of astrocyte water trafficking, thereby controlling brain volume.