Examinando por Autor "Campoy, Sergio"

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    Effectiveness and safety of anti-CGRP monoclonal antibodies in patients over 65 years: a real-life multicentre analysis of 162 patients
    (BioMed Central Ltd, 2023-06-02) Muñoz-Vendrell, Albert; Campoy, Sergio; Caronna, Edoardo; Alpuente Ruiz, Alicia; Torres Ferrús, Marta; Nieves Castellanos, Candela ; Olivier, M.; Campdelacreu Fumadó, Jaume; Prat, Joan; Camiña Muñiz, J.; Molina Martínez, Francisco José ; Mínguez Olaondo, Ane; Ruibal, M.; Santos Lasaosa, Sonia; Navarro Pérez, María Pilar; Morollón, Noemí ; López Bravo, Alba ; Cano Sánchez, Luis Miguel; García-Sánchez, S.M.; García-Ull, Jesica; Rubio-Flores, Laura; Gonzalez Martinez, Alicia; Quintas, Sonia ; Echavarría Íñiguez, Ana ; Gil Luque, Sendoa; Castro-Sánchez, M.V.; Adell Ortega, V.; García Alhama, J.; Berrocal-Izquierdo, N.; Belvís Nieto, Roberto; Díaz Insa, Samuel ; Pozo Rosich, Patricia ; Huerta Villanueva, Mariano
    Background: Anti-CGRP monoclonal antibodies have shown notable effectiveness and tolerability in migraine patients; however, data on their use in elderly patients is still lacking, as clinical trials have implicit age restrictions and real-world evidence is scarce. In this study, we aimed to describe the safety and effectiveness of erenumab, galcanezumab and fremanezumab in migraine patients over 65 years old in real-life. Methods: In this observational real-life study, a retrospective analysis of prospectively collected data from 18 different headache units in Spain was performed. Migraine patients who started treatment with any anti-CGRP monoclonal antibody after the age of 65 years were included. Primary endpoints were reduction in monthly migraine days after 6 months of treatment and the presence of adverse effects. Secondary endpoints were reductions in headache and medication intake frequencies by months 3 and 6, response rates, changes in patient-reported outcomes and reasons for discontinuation. As a subanalysis, reduction in monthly migraine days and proportion of adverse effects were also compared among the three monoclonal antibodies. Results: A total of 162 patients were included, median age 68 years (range 65–87), 74.1% women. 42% had dyslipidaemia, 40.3% hypertension, 8% diabetes, and 6.2% previous cardiovascular ischaemic disease. The reduction in monthly migraine days at month 6 was 10.1 ± 7.3 days. A total of 25.3% of patients presented adverse effects, all of them mild, with only two cases of blood pressure increase. Headache and medication intake frequencies were significantly reduced, and patient-reported outcomes were improved. The proportions of responders were 68%, 57%, 33% and 9% for reductions in monthly migraine days ≥ 30%, ≥ 50%, ≥ 75% and 100%, respectively. A total of 72.8% of patients continued with the treatment after 6 months. The reduction in migraine days was similar for the different anti-CGRP treatments, but fewer adverse effects were detected with fremanezumab (7.7%). Conclusions: Anti-CGRP mAbs are safe and effective treatments in migraine patients over 65 years old in real-life clinical practice. Graphical Abstract: [Figure not available: see fulltext.]
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    Evaluation of the effectiveness and safety of anti-CGRP monoclonal antibodies in patients with migraine and autoimmune diseases: IMMUNO-CGRP study
    (John Wiley and Sons Inc, 2026-06) García Castillo, María ; Sierra-Mencía, Álvaro; Caronna, Edoardo ; Toledo-Alfocea, Daniel ; Jaimes, Alex; Urtiaga, Sarai; Casas-Limón, Javier ; Muñoz-Vendrell, Albert ; Santos Lasaosa, Sonia; García Martín, Valvanuz ; Martín Ávila, Guillermo; Polanco, Marcos; Villar-Martínez, María Dolores; Trevino-Peinado, Cristina; Rubio-Flores, Laura; Sánchez Soblechero, A; Portocarrero Sánchez, Leonardo; Luque-Buzo, Elisa; Lozano Ros, Alberto; Gago Veiga, Ana Beatriz; Díaz de Terán, Javier; Recio García, Andrea; Canales Rodríguez, Javiera; Gómez García, Andrea; González Salaices, Marta ; Campoy, Sergio; Mínguez Olaondo, Ane; Maniataki, Stefania; González-Quintanilla, Vicente; Porta-Etessam, Jesús; Cuadrado, María Luz; Guerrero Peral, Ángel Luis; Pozo Rosich, Patricia; Rodríguez Vico, Jaime; Huerta Villanueva, Mariano; Pascual, Julio; Goadsby, Peter J.; González Martínez, Alicia
    Objective: This study aimed to evaluate demographic characteristics, treatment effectiveness, and safety outcomes in patients with migraine undergoing anti-calcitonin gene-related peptide (CGRP) treatments regarding the presence of autoimmune diseases. Background: CGRP has an important role in migraine pathophysiology through neuronal modulation in the trigeminovascular nociceptive system and activation of neuro-inflammatory cascades. We hypothesized that autoimmune diseases may influence treatment response and safety profiles in patients with migraine treated with anti-CGRP treatments. Methods: This was a retrospective multicenter, age- and sex-matched cohort study in headache units/headache clinics in Spain and United Kingdom between May 2024 and May 2025 including patients treated with CGRP monoclonal antibodies from prospectively collected cohorts. Patients were assessed for demographics, migraine-related characteristics, treatment effectiveness (monthly migraine days [MMD] and/or monthly headache days [MHD]), and safety outcomes. The main outcome was the effectiveness measured by ≥50% response rate in MMD between the two groups. Secondary outcomes included other effectiveness measurements regarding the number of MMD and MHD and treatment emerging adverse events. Results: A total of 388 patients with migraine under anti-CGRP treatments (194 with autoimmune diseases and 194 age- and sex-matched controls without autoimmune diseases) were included. The proportion of patients achieving a ≥50% response rate in MMD was higher in patients without autoimmune diseases at 6 (69% vs. 53%; p = 0.006) and 9 months (74% vs. 52%; p = 0.006). Treatment emerging adverse events were comparable between the two groups (35% vs. 38%; p = 0.575). Patients with autoimmune disease had a significantly lower likelihood of achieving a ≥50% response in MMD compared with those without autoimmune disease (adjusted odds ratio, 0.61; 95% confidence interval, 0.44–0.85; p = 0.006), independent of comorbid depression and medication overuse. Conclusions: Our study shows that anti-CGRP treatments are effective and safe for patients with migraine regardless the presence of autoimmune diseases, although an increased treatment response in patient without autoimmune disorders compared to patients with autoimmune disorders was observed. These findings highlight the need for early intervention, tailored strategies, and vigilant monitoring in patients with migraine and autoimmune disorders. Further research should explore immunomodulatory approaches to enhance outcomes. (Figure presented.).