Examinando por Autor "Barreiro de Acosta, Manuel"

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    Immigrant IBD patients in Spain are younger, have more extraintestinal manifestations and use more biologics than native patients
    (Frontiers Media, 2022-02-01) Gutiérrez Casbas, Ana ; Zapater Hernández, Pedro ; Ricart, Elena ; González-Vivó, Maria ; Gordillo Ábalos, Jordi ; Olivares, David ; Vera Mendoza, María Isabel ; Mañosa, Míriam ; Pérez Gisbert, Javier ; Aguas, Mariam ; Sánchez Rodríguez, Eugenia ; Boscá Watts, Marta Maia ; Laredo, Viviana ; Camps i Aler, Blau; Marín-Jiménez, Ignacio ; Zabana, Yamile ; Martín Arranz, María Dolores ; Muñoz Perez, Roser ; Navarro, Mercè ; Sierra Moros, Eva; Madero Velázquez, Lucía ; Vela González, Milagros ; Pérez Calle, José Lázaro ; Sainz Arnau, Empar ; Calvet Calvo, Xavier ; Arias, Lara ; Morales Alvarado, Victor Jair ; Bermejo San José, Fernando ; Fernández-Salazar, Luis Ignacio ; Van Domselaar, Manuel ; Castro Parga, María Luisa de ; Rodríguez Gutiérrez, Cristina ; Muñoz Villafranca, Carmen ; Lorente Poyatos, Rufo Humberto ; Rivero Tirado, Montserrat; Iglesias Flores, Eva ; Herreros Martinez, Belen ; Busquets Casals, David; Riera Oliver, Joan; Martínez Montiel, Pilar ; Roldon Golet, Marta ; Roncero García-Escribano, Óscar ; Hinojosa del Valle, Esther ; Sierra Ausín, Mónica ; Barrio Andrés, Jesús ; Francisco García, Ruth de ; Huguet-Malavés, Jose María ; Merino Ochoa, Olga ; Carpio López, Daniel ; Ginard Vicens, Daniel; Muñoz Núñez, José Fernando ; Piqueras, Marta ; Almela Notari, Pedro ; Argüelles Arias, Federico ; Alcaín Martínez, Guillermo ; Bujanda Fernández de Piérola, Luis ; Manceñido Marcos, Noemí ; Lucendo Villarín, Alfredo José ; Varela Trastoy, Pilar ; Rodríguez Lago, Iago ; Charola Ramos, Laura Andrea ; Sempere Robles, L. ; Sese Abizanda, Eva ; Barreiro de Acosta, Manuel ; Domènech, Eugeni ; Francés Guarinos, Rubén José
    Background: Previous studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. Methods: Prospective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients. Results: We included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 ± 12 vs. 54 ± 16 years, p < 0.001), had been diagnosed younger (31 ± 12 vs. 36 ± 15 years, p < 0.001), and had a shorter disease duration (14 ± 7 vs. 18 ± 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92–2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0–1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses. Conclusions: Compared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe
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    The natural history of extraintestinal manifestations after surgery in inflammatory bowel disease: never give up!
    (John Wiley and Sons Inc, 2021-09-25) Rodríguez Lago, Iago ; Barreiro de Acosta, Manuel
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    Single-cell analysis reveals significant transcriptomic alterations in preclinical Crohn’s disease
    (Frontiers Media SA, 2025-05-22) Kioroglou, Dimitrios; Egia Mendikute, Leire; Palazón García, Francisco de Asís; Barreiro de Acosta, Manuel; Rodríguez Lago, Iago; Martínez Marigorta, Urko
    Despite the increasing incidence of Crohn’s disease (CD), its early immune disturbances have not all been described yet. We analysed single-cell RNASeq data from peripheral blood mononuclear cells of patients with incidentally-diagnosed CD, and compared their gene expression profile to healthy individuals. The main aim of our study was to perform an exploratory analysis of how the subclinical inflammatory process is modifying the individual’s immunologic environment while the patient is still in the preclinical period.
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    Subclinical bowel inflammation increases healthcare resources utilization and steroid use before diagnosis of inflammatory bowel disease
    (John Wiley and Sons Inc, 2023-02) Rodríguez Lago, Iago; Aguirre Larracoechea, Urko ; Ramírez de la Piscina, Patricia; Muñagorri, Ana I.; Zapata, Eva ; Higuera, Rebeca; Montalvo, Isabel; Iriarte, Ainara; Fernández Calderón, María; Arreba González, Paz; Carrascosa, Juan; Cabriada, José Luis ; Barreiro de Acosta, Manuel
    Background: Previous data support that the inflammatory process underlying ulcerative colitis (UC) and Crohn's disease (CD) can start years before the diagnosis. The aim of this study was to determine if patients with an incidental diagnosis of UC or CD demonstrate an increase in healthcare utilization in the years preceding the symptomatic onset of the disease. Methods: We performed a multicenter, retrospective, hospital-based, case-control study. Patients with an incidental diagnosis of UC or CD during the colorectal cancer screening program at 9 hospitals were included. Cases were matched 1:3 and compared separately with two control populations: one including healthy non-IBD subjects adjusted by gender, age, and date, excluding those with visits to Gastroenterology; and a second control cohort of UC/CD patients with symptomatic onset. Results: A total of 124 patients with preclinical inflammatory bowel disease (IBD) were included (87 UC, 30 CD, 7 IBD unclassified; median age 56 years). Patients with preclinical IBD showed an increase in the number of visits to Primary Care up to 3 and 5 years before diagnosis (aIRR 1.59, 95% CI [1.37–1.86], p = 0.001; aIRR 1.43, 95% CI [1.24–1.67], p = 0.01) and more frequent use of steroids (aOR 2.84, 95% CI [1.21–6.69], p = 0.03; aOR 2.25, 95% CI [1.06–4.79], p = 0.04) compared to matched non-IBD healthy controls, respectively. In contrast, patients with a symptomatic onset visited Primary Care less frequently, but they had an increase in the number of visits to Emergency Department, specialist care, sick-leaves, CT/ultrasound examinations, and use of antibiotics or systemic steroids. Conclusions: There is an increased need for medical assistance and use of systemic steroids during the presymptomatic phase of IBD. These results will help in establishing new tools for early identification of IBD in the future.
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    Transmural cross-sectional findings and bowel damage assessment in preclinical Crohn’s disease: a case-control study
    (Springer Nature, 2024-06-14) Rodríguez Lago, Iago; Aduna, Marta; Ramírez de la Piscina, Patricia; Merino, Olga; Carrascosa, Juan; Higuera, Rebeca; Maíz, Ainara; Zapata, Eva; Cabriada, José Luis; Barreiro de Acosta, Manuel
    Purpose: Crohn’s disease (CD) is a progressive disorder leading to cumulative bowel damage. The Lémann index is a validated tool that can help in monitoring the progression of the disease and evaluating the effectiveness of different therapies. Our aim was to describe the main radiological findings in incidentally diagnosed CD and to evaluate bowel damage in this subgroup compared to patients diagnosed at later stages. Methods: Patients with an incidental diagnosis of CD during the colorectal cancer screening program were compared to controls with a CD cohort diagnosed after symptomatic onset and matched 1:1 by disease extent. All cross-sectional examinations were centrally read, performing a descriptive analysis of the main findings and calculation of Lémann index. Results: Thirty-eight patients were included: 19 with preclinical CD (median age 55 years (IQR, 54–62), 53% male, 74% non-smokers; 74% B1 and 26% B2) and 19 matched-controls with symptomatic CD. In those with preclinical CD, the most frequent transmural findings on MRE were contrast enhancement (79%), wall thickening (79%), followed by lymphadenopathy (68%), edema (42%), and increased vascularity (42%). Among those with strictures, controls showed a higher rate of preestenotic dilation (100% vs. 0%, p = 0.01). Bowel damage assessment revealed no statistically significant differences in the Lémann index between preclinical CD and controls (p = 0.95). A statistically significant higher score in the colonic/rectum score was observed (p = 0.014). Conclusion: Patients with preclinical CD demonstrate similar radiological findings and degree of bowel damage as new-onset symptomatic CD.