Examinando por Autor "Arango Lasprilla, Juan Carlos"

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    Group-level progressive alterations in brain connectivity patterns revealed by diffusion-tensor brain networks across severity stages in Alzheimer's disease
    (Frontiers Media S.A., 2017-07-07) Rasero, Javier; Alonso Montes, Carmen ; Diez, Ibai; Olabarrieta Landa, Laiene ; Remaki, Lakhdar; Escudero Martínez, Iñaki ; Mateos Goñi, Beatriz ; Bonifazi, Paolo ; Fernández Martínez, Manuel; Arango Lasprilla, Juan Carlos; Stramaglia, Sebastiano; Cortes, Jesús M.
    Alzheimer's disease (AD) is a chronically progressive neurodegenerative disease highly correlated to aging. Whether AD originates by targeting a localized brain area and propagates to the rest of the brain across disease-severity progression is a question with an unknown answer. Here, we aim to provide an answer to this question at the group-level by looking at differences in diffusion-tensor brain networks. In particular, making use of data from Alzheimer's Disease Neuroimaging Initiative (ADNI), four different groups were defined (all of them matched by age, sex and education level): G1 (N1 = 36, healthy control subjects, Control), G2 (N2 = 36, early mild cognitive impairment, EMCI), G3 (N3 = 36, late mild cognitive impairment, LMCI) and G4 (N4 = 36, AD). Diffusion-tensor brain networks were compared across three disease stages: stage I (Control vs. EMCI), stage II (Control vs. LMCI) and stage III (Control vs. AD). The group comparison was performed using the multivariate distance matrix regression analysis, a technique that was born in genomics and was recently proposed to handle brain functional networks, but here applied to diffusion-tensor data. The results were threefold: First, no significant differences were found in stage I. Second, significant differences were found in stage II in the connectivity pattern of a subnetwork strongly associated to memory function (including part of the hippocampus, amygdala, entorhinal cortex, fusiform gyrus, inferior and middle temporal gyrus, parahippocampal gyrus and temporal pole). Third, a widespread disconnection across the entire AD brain was found in stage III, affecting more strongly the same memory subnetwork appearing in stage II, plus the other new subnetworks, including the default mode network, medial visual network, frontoparietal regions and striatum. Our results are consistent with a scenario where progressive alterations of connectivity arise as the disease severity increases and provide the brain areas possibly involved in such a degenerative process. Further studies applying the same strategy to longitudinal data are needed to fully confirm this scenario.
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    Ítem
    Sexual functioning, desire, and satisfaction in women with TBI and healthy controls
    (Hindawi Limited, 2015-10-18) Strizzi, Jenna; Olabarrieta Landa, Laiene; Pappadis, Monique; Olivera, Silvia Leonor; Valdivia Tangarife, Edgar Ricardo; Fernandez Agis, Inmaculada; Perrin, Paul B.; Arango Lasprilla, Juan Carlos
    Traumatic brain injury (TBI) can substantially alter many areas of a person's life and there has been little research published regarding sexual functioning in women with TBI. Methods. A total of 58 women (29 with TBI and 29 healthy controls) from Neiva, Colombia, participated. There were no statistically significant differences between groups in sociodemographic characteristics. All 58 women completed the Sexual Quality of Life Questionnaire (SQoL), Female Sexual Functioning Index (FSFI), Sexual Desire Inventory (SDI), and the Sexual Satisfaction Index (ISS). Results. Women with TBI scored statistically significantly lower on the SQoL (p<0.001), FSFI subscales of desire (p<0.05), arousal (p<0.05), lubrication (p<0.05), orgasm (p<0.05), and satisfaction (p<0.05), and the ISS (p<0.001) than healthy controls. Multiple linear regressions revealed that age was negatively associated with some sexuality measures, while months since the TBI incident were positively associated with these variables. Conclusion. These results disclose that women with TBI do not fare as well as controls in these measures of sexual functioning and were less sexually satisfied. Future research is required to further understand the impact of TBI on sexual function and satisfaction to inform for rehabilitation programs.
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    Ítem
    Situación actual de la práctica profesional de la neuropsicología en México
    (Universidad del Norte, 2015-09-17) Fonseca Aguilar, Paola; Olabarrieta Landa, Laiene; Rivera Camacho, Diego; Aguayo Arelis, Adriana; Ortiz Jiménez, Xóchitl Angélica; Rabago Barajas, Brenda Viridiana; Rodríguez Agudelo, Yaneth; Álvarez, Enrique; Arango Lasprilla, Juan Carlos
    El objetivo de este estudio fue conocer las características de la práctica neuropsicológica en México, incluyendo la formación profesional, la situación laboral actual, el proceso de evaluación y diagnóstico, rehabilitación, docencia e investigación. Participaron 171 profesionales en México, quienes respondieron una encuesta electrónica entre el 1 de julio del 2013 y el 1 de enero del 2014. El 76% indicó haber obtenido su entrenamiento en neuropsicología durante el postgrado y, aunque indicaron estar muy satisfechos con su labor, su satisfacción con el salario fue menor. La mayoría trabajan con personas con problemas de aprendizaje (78%) y trastornos de atención e hiperactividad (74%). El 91% se dedica a evaluación y diagnóstico, 61% a rehabilitación, 67% a docencia y 60% a investigación. Los problemas más comunes fueron la falta de datos normativos (63%) y el alto coste de los test (58%). Las barreras más observadas en el desarrollo de la neuropsicología fueron la falta de colaboración entre los profesionales y la falta de programas de formación clínica. Durante las últimas décadas se han logrado importantes avances a nivel profesional en el campo de la neuropsicología en México. Sin embargo, aún quedan aspectos por mejorar como el establecimiento de criterios para la regulación de la práctica neuropsicológica en el país.