Examinando por Autor "Aguas, Mariam"

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    Immigrant IBD patients in Spain are younger, have more extraintestinal manifestations and use more biologics than native patients
    (Frontiers Media, 2022-02-01) Gutiérrez Casbas, Ana ; Zapater Hernández, Pedro ; Ricart, Elena ; González-Vivó, Maria ; Gordillo Ábalos, Jordi ; Olivares, David ; Vera Mendoza, María Isabel ; Mañosa, Míriam ; Pérez Gisbert, Javier ; Aguas, Mariam ; Sánchez Rodríguez, Eugenia ; Boscá Watts, Marta Maia ; Laredo, Viviana ; Camps i Aler, Blau; Marín-Jiménez, Ignacio ; Zabana, Yamile ; Martín Arranz, María Dolores ; Muñoz Perez, Roser ; Navarro, Mercè ; Sierra Moros, Eva; Madero Velázquez, Lucía ; Vela González, Milagros ; Pérez Calle, José Lázaro ; Sainz Arnau, Empar ; Calvet Calvo, Xavier ; Arias, Lara ; Morales Alvarado, Victor Jair ; Bermejo San José, Fernando ; Fernández-Salazar, Luis Ignacio ; Van Domselaar, Manuel ; Castro Parga, María Luisa de ; Rodríguez Gutiérrez, Cristina ; Muñoz Villafranca, Carmen ; Lorente Poyatos, Rufo Humberto ; Rivero Tirado, Montserrat; Iglesias Flores, Eva ; Herreros Martinez, Belen ; Busquets Casals, David; Riera Oliver, Joan; Martínez Montiel, Pilar ; Roldon Golet, Marta ; Roncero García-Escribano, Óscar ; Hinojosa del Valle, Esther ; Sierra Ausín, Mónica ; Barrio Andrés, Jesús ; Francisco García, Ruth de ; Huguet-Malavés, Jose María ; Merino Ochoa, Olga ; Carpio López, Daniel ; Ginard Vicens, Daniel; Muñoz Núñez, José Fernando ; Piqueras, Marta ; Almela Notari, Pedro ; Argüelles Arias, Federico ; Alcaín Martínez, Guillermo ; Bujanda Fernández de Piérola, Luis ; Manceñido Marcos, Noemí ; Lucendo Villarín, Alfredo José ; Varela Trastoy, Pilar ; Rodríguez Lago, Iago ; Charola Ramos, Laura Andrea ; Sempere Robles, L. ; Sese Abizanda, Eva ; Barreiro de Acosta, Manuel ; Domènech, Eugeni ; Francés Guarinos, Rubén José
    Background: Previous studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. Methods: Prospective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients. Results: We included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 ± 12 vs. 54 ± 16 years, p < 0.001), had been diagnosed younger (31 ± 12 vs. 36 ± 15 years, p < 0.001), and had a shorter disease duration (14 ± 7 vs. 18 ± 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92–2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0–1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses. Conclusions: Compared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe