Gutiérrez Casbas, AnaZapater Hernández, PedroRicart, ElenaGonzález-Vivó, MariaGordillo Ábalos, JordiOlivares, DavidVera Mendoza, María IsabelMañosa, MíriamPérez Gisbert, JavierAguas, MariamSánchez Rodríguez, EugeniaBoscá Watts, Marta MaiaLaredo, VivianaCamps i Aler, BlauMarín-Jiménez, IgnacioZabana, YamileMartín Arranz, María DoloresMuñoz Perez, RoserNavarro, MercèSierra Moros, EvaMadero Velázquez, LucíaVela González, MilagrosPérez Calle, José LázaroSainz Arnau, EmparCalvet Calvo, XavierArias, LaraMorales Alvarado, Victor JairBermejo San José, FernandoFernández-Salazar, Luis IgnacioVan Domselaar, ManuelCastro Parga, María Luisa deRodríguez Gutiérrez, CristinaMuñoz Villafranca, CarmenLorente Poyatos, Rufo HumbertoRivero Tirado, MontserratIglesias Flores, EvaHerreros Martinez, BelenBusquets Casals, DavidRiera Oliver, JoanMartínez Montiel, PilarRoldon Golet, MartaRoncero García-Escribano, ÓscarHinojosa del Valle, EstherSierra Ausín, MónicaBarrio Andrés, JesúsFrancisco García, Ruth deHuguet-Malavés, Jose MaríaMerino Ochoa, OlgaCarpio López, DanielGinard Vicens, DanielMuñoz Núñez, José FernandoPiqueras, MartaAlmela Notari, PedroArgüelles Arias, FedericoAlcaín Martínez, GuillermoBujanda Fernández de Piérola, LuisManceñido Marcos, NoemíLucendo Villarín, Alfredo JoséVarela Trastoy, PilarRodríguez Lago, IagoCharola Ramos, Laura AndreaSempere Robles, L.Sese Abizanda, EvaBarreiro de Acosta, ManuelDomènech, EugeniFrancés Guarinos, Rubén José2025-05-142025-05-142022-02-01Gutiérrez A, Zapater P, Ricart E, González-Vivó M, Gordillo J, Olivares D, Vera I, Mañosa M, Gisbert JP, Aguas M, Sánchez-Rodríguez E, Bosca-Watts M, Laredo V, Camps B, Marín-Jiménez I, Zabana Y, Martín-Arranz MD, Muñoz R, Navarro M, Sierra E, Madero L, Vela M, Pérez-Calle JL, Sainz E, Calvet X, Arias L, Morales V, Bermejo F, Fernández-Salazar L, Van Domselaar M, De Castro L, Rodríguez C, Muñoz-Villafranca C, Lorente R, Rivero M, Iglesias E, Herreros B, Busquets D, Riera J, Martínez-Montiel MP, Roldón M, Roncero O, Hinojosa E, Sierra M, Barrio J, De Francisco R, Huguet J, Merino O, Carpio D, Ginard D, Muñoz F, Piqueras M, Almela P, Argüelles-Arias F, Alcaín G, Bujanda L, Manceñido N, Lucendo AJ, Varela P, Rodríguez-Lago I, Ramos L, Sempere L, Sesé E, Barreiro-de Acosta M, Domènech E and Francés R (2022). Immigrant IBD patients in Spain are younger, have more extraintestinal manifestations and use more biologics than native patients. Frontiers in Medicine, 9. https://doi.org/10.3389/FMED.2022.82390010.3389/FMED.2022.823900https://hdl.handle.net/20.500.14454/2748Background: Previous studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. Methods: Prospective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients. Results: We included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 ± 12 vs. 54 ± 16 years, p < 0.001), had been diagnosed younger (31 ± 12 vs. 36 ± 15 years, p < 0.001), and had a shorter disease duration (14 ± 7 vs. 18 ± 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92–2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0–1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses. Conclusions: Compared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europeeng© 2022 Gutiérrez, Zapater, Ricart, González-Vivó, Gordillo, Olivares, Vera, Mañosa, Gisbert, Aguas, Sánchez-Rodríguez, Bosca-Watts, Laredo, Camps, Marín-Jiménez, Zabana, Martín-Arranz, Muñoz, Navarro, Sierra, Madero, Vela, Pérez-Calle, Sainz, Calvet, Arias, Morales, Bermejo, Fernández-Salazar, Van Domselaar, De Castro, Rodríguez, Muñoz-Villafranca, Lorente, Rivero, Iglesias, Herreros, Busquets, Riera, Martínez-Montiel, Roldón, Roncero, Hinojosa, Sierra, Barrio, De Francisco, Huguet, Merino, Carpio, Ginard, Muñoz, Piqueras, Almela, Argüelles-Arias, Alcaín, Bujanda, Manceñido, Lucendo, Varela, Rodríguez-Lago, Ramos, Sempere, Sesé, Barreiro-de Acosta, Domènech and FrancésBiologicsCrohn's diseaseImmigrantInflammatory bowel diseasePhenotypeUlcerative colitisjournal article2025-05-142296-858X