Montoya Murillo, GenovevaIbarretxe Bilbao, NaroaPeña Lasa, JavierOjeda del Pozo, Natalia2025-10-032025-10-032020-05Montoya-Murillo, G., Ibarretxe-Bilbao, N., Peña, J., & Ojeda, N. (2020). Effects of cognitive rehabilitation on cognition, apathy, quality of life, and subjective complaints in the elderly: a randomized controlled trial. American Journal of Geriatric Psychiatry, 28(5), 518-529. https://doi.org/10.1016/J.JAGP.2019.10.0111064-748110.1016/J.JAGP.2019.10.011https://hdl.handle.net/20.500.14454/3847Objective: To determine the efficacy of a new-generation integrative cognitive rehabilitation (CR) program (Rehacop) on cognition, clinical symptoms, quality of life (QoL), and subjective complaints in the elderly. Design: A randomized controlled trial study with a cohort of elderly people over 55 years of age. Setting: Communities of the Basque Country (Spain). Participants: A total of 124 elderly participants (aged 79.00 ± 8.85 years) were randomized in the Rehacop group (RG) (n = 62) and control group (CG) (n = 62). Intervention: The RG attended 39 CR sessions for 3 months (3 sessions/week, 60-minute/session) with the Rehacop program. The CG performed occupational tasks with the same frequency and duration as the RG. Methods: Participants underwent a neuropsychological assessment at baseline and post-treatment which included cognitive, clinical, and functional tests. In addition, participants and their formal caregivers completed a subjective complaints questionnaire. The data were analyzed according to the intention to treat analysis and with participants who completed the study. This study was registered at clinicaltrials.gov (NCT03435029). Results: The RG showed significant improvements compared to the CG in neurocognition (ANCOVA timexgroup interaction effect size (ηp 2)=0.05, 90% confidence interval (CI) = 0.00–0.12). The RG also reduced apathy (ηp 2=0.06, 90% CI = 0.01–0.15) and participants’ subjective complaints (ηp 2=0.11, 90% CI = 0.03–0.21) and improved QoL (ηp 2=0.08, 90% CI = 0.01–0.17). Conclusions: Participants who attended the intervention improved their cognition, QoL, and reduced apathy and subjective complaints after treatment. These findings provide a new understanding of the benefits of CR in the elderly.eng© 2019 The AuthorsApathyCognitive rehabilitationElderlyQuality of lifeRandomized controlled trialRehacopSubjective complaintsjournal article2025-10-031545-7214