Uribe, CarmeJunqué i Plaja, CarmeGómez Gil, EstherAbos Ortega, AlexandraMueller, Sven C.Guillamon, Antonio2025-08-252025-08-252020-05-15Uribe, C., Junque, C., Gómez-Gil, E., Abos, A., Mueller, S. C., & Guillamon, A. (2020). Data for functional MRI connectivity in transgender people with gender incongruence and cisgender individuals. En Data in Brief (Vol. 31). Elsevier Inc. https://doi.org/10.1016/J.DIB.2020.10569110.1016/J.DIB.2020.105691https://hdl.handle.net/20.500.14454/3405We provide T2*-weighted and T1-weighted images acquired on a 3T MRI scanner obtained from 17 transwomen and 29 transmen with gender incongruence; and 22 ciswomen and 19 cismen that identified themselves to the sex assigned at birth. Data from three different techniques that describe global and regional connectivity differences within functional resting-state networks in transwomen and transmen with early-in-life onset gender incongruence are provided: (1) we obtained spatial maps from data-driven independent component analysis using the melodic tool from FSL software; (2) we provide the functional networks interactions of two functional atlases’ seeds from a seed-to-seed approach; (3) and global graph-theoretical metrics such as the smallworld organization, and the segregation and integration properties of the networks. Interpretations of the present dataset can be found in the original article, doi:10.1016/j.neuroimage.2020.116613 [1]. The original and processed nifti images are available in Mendeley datasets. In addition, correlation matrices for the seed-to-seed and graph-theory analyses as well as the graph-theoretical measures were made available in Matlab files. Finally, we present supplementary information for the original article.eng© 2020TheAuthor(s)Functional MRIGender identityGender incongruenceGraph theoryIndependent component analysis (ICA)Resting-state connectivitySeed-based analysisTransmenTranswomendata paper2025-08-252352-3409