DeustoTeka
DeustoTeka recoge la producción científica del personal docente e investigador de la Universidad de Deusto. Su propósito es reunir, archivar, preservar y aumentar la visibilidad en acceso abierto de los resultados de investigación.
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Improving membranous urethral length measurements on prostate MRI: a comparison of online training methods
(Springer Science and Business Media Deutschland GmbH, 2026-08) Goedegebuure, Elisabeth P.; Boellaard, T.N.; van Dijk-de Haan, M.C.; Heijmink, S.W.T.P.J.; Hagens, M.J.; Tissier, R.; van Griethuysen, J.J.M.; Khmelinkskii, A.; Beets-Tan, R.G.H.; Schoots, I.G.; Lambregts, D.M.J.; Zerunian, M.; Withey, S.; de Wit, B.W.K.; van Westerveld, P.P.; Weimar, E.A.M.; de Walle, S.F.; Voogt, M.J.; Vesel, M.; Verhoeff, E.; Vennix, S.; Vainak, N.; Ursprung, S.; Turgut, A.Ç.; Tol, S.; Tiidermann, M.; Terra, C.; Tapia Proaño, M.J.; van Stiphout, R.S.A.; Stanzione, A.; Somers, I.; Somasundaram, A.; Solak, E.P.; Smit, R.S.; Silva, M.C.; Šifer, K.K.; Shakur, A.; Schouten, L.J.; Salvador Izquierdo, Rafael; Reinhard, R.; Ramselaar, A.; Raat, H.P.J.; Ponsiglione, A.; van Oudheusden, T.; van Oorschot, N.; Onit, R.-D.; Ocantos, J.A.; Obmann, V.C.; Noordmans, J.; Nederend, J.; Moreira, A.S.L.; Minis-Rutten, I.; de Mello Ando, S.; Matic, V.; Masci, B.; Mannacio, L.; Manganaro, P.M.J.; Mai C.; Lorea, M.; Lee, K.-L.; Kobus, C.; van Kelckhoven, B.-J.; Kasap, H.; Hernández-Mancera, J.; Hanrath-Vos, E.; Groote, M.E.; Gonçalves, M.L.R.R.; Girometti, R.; Geetha Virupakshappa, A.K.; Geenen, R.W.F.; Gaudiano, C.; García-Gil García, J.C.; García Baizán, Alejandra ; Garbajs, M.; Franco, P.N.; Forte, V.; Falińska, H.; Durmaz, S.; Duczkowska, M.; De Visschere, P.; Cuocolo, R.; Di Costanzo, G.; Chen, D.Z.; Caglic, I.; Bruining, A.; Brembilla, G.; Barrett, T.; Baerveldt, R.C.; Avesani, G.; Arita, Y.; Álvarez-Hornia Pérez, Eduardo ; Agrotis, G.
Objectives: This study compared three online training methods to enhance diagnostic performance, reader confidence, and interreader agreement in membranous urethral length (MUL) measurements. Materials and methods: Ninety-nine study participants were asked to measure the MUL on 20 test cases at the start of the study and rated their confidence level. Participants were then divided semi-randomly into three training groups: Group A (written instructions), Group B (1-month self-study program with case feedback using a dedicated web platform), and Group C (1-day online expert-led case-based training). Groups B and C worked through an identical set of 40 cases. One week after completing training, participants evaluated the same 20 test cases. Diagnostic performance (using expert reference standard), interreader agreement (intraclass correlation coefficient, ICC), and reader confidence levels were compared before and after training. Participants completed a questionnaire evaluating their perceptions of the training. Results: Eighty-one participants (82%) completed the study. All groups demonstrated significant improvements in diagnostic performance and confidence (p < 0.001), with similar outcomes across training groups. Interreader agreement improved from ICC 0.52–0.56 pre-training to 0.74–0.80 post-training. Questionnaire responses indicated most found the training appropriate; however, 17% of Group A felt it was insufficient, while 30–35% of Group C found the expert-led training too time-consuming. Conclusion: All training methods—ranging from minimal, with written instructions only, to more comprehensive case-based programs—effectively improved diagnostic performance, reader confidence and interreader agreement for MUL measurements on prostate MRI. Independent online training offers practical advantages over more time-demanding hands-on sessions, supporting broader clinical implementation of MUL-based individualized continence prediction. Key Points: Question Which method of online training is most effective to train radiologists in measuring the membranous urethral length (MUL) on prostate MRI? Findings 81 radiologists showed significant gains in diagnostic performance, confidence and interreader agreement, with similar results after written instructions, case-based self-study, or hands-on expert-led training. Clinical relevance Enhanced accuracy and interreader consistency achieved through online training can facilitate wider clinical adoption of MUL-based continence prediction, strengthening patient counseling and shared decision making in prostate cancer management.
Evaluation of the effectiveness and safety of anti-CGRP monoclonal antibodies in patients with migraine and autoimmune diseases: IMMUNO-CGRP study
(John Wiley and Sons Inc, 2026-06) García Castillo, María ; Sierra-Mencía, Álvaro; Caronna, Edoardo
; Toledo-Alfocea, Daniel ; Jaimes, Alex; Urtiaga, Sarai; Casas-Limón, Javier
; Muñoz-Vendrell, Albert
; Santos Lasaosa, Sonia; García Martín, Valvanuz
; Martín Ávila, Guillermo; Polanco, Marcos; Villar-Martínez, María Dolores; Trevino-Peinado, Cristina; Rubio-Flores, Laura; Sánchez Soblechero, A; Portocarrero Sánchez, Leonardo; Luque-Buzo, Elisa; Lozano Ros, Alberto; Gago Veiga, Ana Beatriz; Díaz de Terán, Javier; Recio García, Andrea; Canales Rodríguez, Javiera; Gómez García, Andrea; González Salaices, Marta ; Campoy, Sergio; Mínguez Olaondo, Ane; Maniataki, Stefania; González-Quintanilla, Vicente; Porta-Etessam, Jesús; Cuadrado, María Luz; Guerrero Peral, Ángel Luis; Pozo Rosich, Patricia; Rodríguez Vico, Jaime; Huerta Villanueva, Mariano; Pascual, Julio; Goadsby, Peter J.; González Martínez, Alicia
Objective: This study aimed to evaluate demographic characteristics, treatment effectiveness, and safety outcomes in patients with migraine undergoing anti-calcitonin gene-related peptide (CGRP) treatments regarding the presence of autoimmune diseases. Background: CGRP has an important role in migraine pathophysiology through neuronal modulation in the trigeminovascular nociceptive system and activation of neuro-inflammatory cascades. We hypothesized that autoimmune diseases may influence treatment response and safety profiles in patients with migraine treated with anti-CGRP treatments. Methods: This was a retrospective multicenter, age- and sex-matched cohort study in headache units/headache clinics in Spain and United Kingdom between May 2024 and May 2025 including patients treated with CGRP monoclonal antibodies from prospectively collected cohorts. Patients were assessed for demographics, migraine-related characteristics, treatment effectiveness (monthly migraine days [MMD] and/or monthly headache days [MHD]), and safety outcomes. The main outcome was the effectiveness measured by ≥50% response rate in MMD between the two groups. Secondary outcomes included other effectiveness measurements regarding the number of MMD and MHD and treatment emerging adverse events. Results: A total of 388 patients with migraine under anti-CGRP treatments (194 with autoimmune diseases and 194 age- and sex-matched controls without autoimmune diseases) were included. The proportion of patients achieving a ≥50% response rate in MMD was higher in patients without autoimmune diseases at 6 (69% vs. 53%; p = 0.006) and 9 months (74% vs. 52%; p = 0.006). Treatment emerging adverse events were comparable between the two groups (35% vs. 38%; p = 0.575). Patients with autoimmune disease had a significantly lower likelihood of achieving a ≥50% response in MMD compared with those without autoimmune disease (adjusted odds ratio, 0.61; 95% confidence interval, 0.44–0.85; p = 0.006), independent of comorbid depression and medication overuse. Conclusions: Our study shows that anti-CGRP treatments are effective and safe for patients with migraine regardless the presence of autoimmune diseases, although an increased treatment response in patient without autoimmune disorders compared to patients with autoimmune disorders was observed. These findings highlight the need for early intervention, tailored strategies, and vigilant monitoring in patients with migraine and autoimmune disorders. Further research should explore immunomodulatory approaches to enhance outcomes. (Figure presented.).
Sensor placement via large deviations in the Eikonal equation
(Springer Science and Business Media Deutschland GmbH, 2026-03-11) Ftouhi, Ilias; Zuazua, Enrique
In this work, we address the problem of optimally placing a finite number of sensors within a given region so as to minimize the mean or maximal distance to the points of the domain. To tackle this natural geometric performance criterion, formulated in terms of distance functions, we combine tools from geometric analysis with a classical result of Varadhan (Commun Pure Appl Math 20:431–455, 1967), which provides an efficient approximation of the distance function via the solution of a simple elliptic PDE. The effectiveness of the proposed approach is demonstrated through illustrative numerical simulations.
Financial openness, volatility, and the size of productive government
(Asociación Española de Economía, 2011-06) Erauskin Iurrita, Iñaki
This paper analyzes the impact of financial openness on the size of the government in a stochastically growing small open economy when public spending is productive and volatility-reducing using a portfolio approach. The main result of the model is that economies that are more open are associated with a smaller productive public sector. The lower risk associated with more open economies due to risk diversification implies that the government is less inclined to increase the scale of its activity to maximize welfare when productive spending is also volatility-reducing. The empirical evidence based on a sample of 16 OECD countries for the period 1970–2004 broadly supports the main results of the model, even though some results are mixed.
Conducta adaptativa y discapacidad intelectual: 50 años de historia y su incipiente desarrollo en la educación en Chile
(Universidad Austral de Chile, Facultad de Filosofía y Humanidades, 2011) Montero Centeno, Delfín; Lagos, Juan
El artículo pretende describir la génesis del constructo conducta adaptativa, su vinculación con la noción de discapacidad intelectual y poner de relieve la importancia de la conducta adaptativa como criterio para el diagnóstico de discapacidad intelectual. Asimismo, se caracterizará el constructo conducta adaptativa tanto en lo que concierne a sus aspectos legales como a su uso para el diagnóstico en las orientaciones técnicas y los formularios únicos propuestos por el Ministerio de Educación de Chile. Finalmente, se plantea una discusión sobre los aciertos y desaciertos del incipiente desarrollo del uso del constructo conducta adaptativa, en lo que concierne a su utilización en personas con discapacidad intelectual específicamente en contextos educativos.